Department of Biochemistry University of Oxford Department of Biochemistry
University of Oxford
South Parks Road
Oxford OX1 3QU

Tel: +44 (0)1865 613200
Fax: +44 (0)1865 613201
Image showing the global movement of lipids in a model planar membrane
Matthieu Chavent, Sansom lab
Anaphase bridges in fission yeast cells
Whitby lab
Lactose permease represented using bending cylinders in Bendix software
Caroline Dahl, Sansom lab
Epithelial cells in C. elegans showing a seam cell that failed to undergo cytokinesis
Serena Ding, Woollard lab
Collage of Drosophila third instar larva optic lobe
Lu Yang, Davis lab
First year Biochemistry students at a practical class
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Seminars

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TBA TBA Tuesday 28th June 11:00 - 12:00 Professor Haruhiko Koseki Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan Biochemistry Department Seminar "The PCGF6-PRC1 complex suppresses premature activation of meiosis and germ cell related genes in ES cells" Seminar Room, Biochemistry Building, Seminar Room, off South Parks Road OX1 3QU
TBA TBA Wednesday 29th June 14:00 - 15:00 Qinrui Wang, Susan Leung University of Oxford
University of Oxford
SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Friday 1st July 14:30 - 15:30 Dr. Benjamin Rowland Research Associate, Netherlands Cancer Institute Special Seminar "Chromosome organization by SMC complexes: linking sisters and extruding loops” Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Tuesday 5th July 13:00 - 14:00 Prof. Dr. Matthias Mann Director Dept. Proteomics and Signal Transduction, MPI, Germany OUBS Lunch for students doing a Dphil in Biochemistry with Prof Dr Matthias Mann Meeting Room TBA, Biochemistry Building, off South Parks Road OX1 3QU
Lunch for students doing a Dphil in Biochemistry (University of Oxford) with Prof Dr Matthias Mann between 1-2pm. The lunch will be followed by a seminar untitled Proteomics technologies and their application in biomedical research. Attendance to the lunch is free but registration is required (Number of participants is limited). If you're interested please email (oubs@bioch.ox.ac.uk) by Tuesday 28th June with any dietary requirements.
oubs@bioch.ox.ac.uk
TBA TBA Tuesday 5th July 14:00 - 15:00 Prof. Dr. Matthias Mann Director Dept. Proteomics and Signal Transduction, MPI, Germany Biochemistry Department Seminar Proteomics technologies and their application in biomedical research Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
Matthias Mann studied physics and mathematics at Göttingen University in Germany and obtained his Ph.D. in chemical engineering at Yale University. Here he was decisively involved in the development of electrospray ionization, which has become a key technology of the life sciences. As a post-doctoral fellow and later as a professor for bioinformatics at the University of Southern Denmark in Odense, he developed, amongst others techniques, the first bioinformatic search algorithms for peptide fragmentation data and SILAC, a new method of quantitative proteomics and a breakthrough in the mapping of protein interactions. In 2005, Matthias Mann took up a director position at the Max-Planck Institute of Biochemistry in Munich. Here his group continues to address a wide range of biological questions using proteomic technology, as well as to develop this technology. The group is also heavily involved in providing proteomic methods and tools to the community. Most importantly in this regard, they have provided the MaxQuant suite of computational proteomics algorithms; this software promises to significantly advance the state of the field. More recently his group used the SILAC technology in conjunction with MaxQuant to described the first comprehensive identification and quantification of a proteome. (http://www.biochem.mpg.de/en/rd/mann ) In 2009 Dr. Mann was additionally appointed director of the proteomics department of the Novo Nordisk Foundation Center for Protein Research in Copenhagen. http://www.cpr.ku.dk/about/ Matthias Mann has authored and co-authored more than 637 publications with a total citation count of more than 160,000, making him one of the most highly cited researchers worldwide. He has been elected to membership of the European Molecular Biology Organization, Royal Danish Academy of Arts and Sciences and the Leopoldina German National Academy of Sciences as well as to a visiting professorship at Harvard Medical School and has received two honorary degrees from Utrecht University and the University of Dundee, respectively. In 2012 he was awarded the Leibniz Prize from the German Research Foundation, the Ernst Schering Prize, the Louis-Jeantet Foundation Prize for Medicine and the Körber European Science Prize. In 2015 was awarded the Barry L. Karger Medal in Bioanalytical Chemistry and the Theodor Bücher Lecture and Medal as well as the Danish Order of Dannebrog Knights Cross.
head@bioch.ox.ac.uk
TBA TBA Thursday 7th July 13:00 - 14:00 Gary Daughdrill University of South Florida Biochemistry Department Seminar "Intrinsic disorder controls the function of p53 and other cancer-associated IDPs" Biochemistry Seminar Room, Biochemistry Building, Biochemistry Seminar Room, off South Parks Road OX1 3QU
p53 is a tumor suppressor and cell cycle regulator that is activated by protein-protein interactions and posttranslational modifications (PTMs). Deletion or mutation of p53 can dramatically increase susceptibility to cancer. p53 is also an intrinsically disordered protein (IDP). IDPs are highly dynamic, do not form stable tertiary structures, and contain variable amounts of transient secondary structure. IDP domains are hotspots for PTMs and they frequently mediate protein-protein interactions through coupled folding and binding. IDP domains that interact with other proteins can contain defined levels of transient secondary structure that resemble their complex-bound structure11. These levels of residual structure can modulate binding affinities with other proteins by tuning the change in conformational entropy that occurs during the coupled folding and binding reaction. We recently showed that levels of residual helicity in the disordered p53 transcriptional activation domain (p53TAD) controlled the binding affinity to the E3 ubiquitin ligase Mdm2, both in vitro and inside living cells. The levels of residual helicity in free p53TAD were controlled by conserved prolines flanking the Mdm2 binding site. Mutating these prolines to alanine resulted in higher p53TAD helicity and stronger Mdm2 binding. This stronger Mdm2 binding inhibits phosphorylation of p53 and leads directly to more rapid degradation of p53 following DNA damage. Lower levels of p53 reduce target gene expression and prevent cell cycle arrest. Our results indicate that precise levels of intrinsic disorder and residual helicity are necessary for regulating the p53-signaling network and changing the levels of disorder will modify the effects of phosphorylation and other PTMs. We are currently investigating whether changing the levels of disorder for other cancer associated IDPs like the myeoblastosis transcription factor family member, cMyb, and the mixed lineage leukemia protein, MLL, control their function.
colin.kleanthous@bioch.ox.ac.uk
TBA TBA Thursday 7th July 14:00 - 15:00 Julia Busch University of Oxford SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Thursday 14th July 14:00 - 15:00 Akshay Sridhar University of Oxford SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Thursday 21st July 14:00 - 15:00 Dr Eiji Yamamoto Keio University SBCB Seminar Series Guest SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Tuesday 26th July 14:00 - 15:00 Dr Adam W Smith University of Akron, Ohio, USA SBCB Seminar Series Guest SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Thursday 28th July 14:00 - 15:00 Dr Antreas Kalli University of Oxford SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Monday 17th October 13:00 - 14:00 Dr. Dirk Schübeler Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 5th December 13:00 - 14:00 Professor Sadaf Farooqi PhD, FRCP, FMedSci WT Senior Clinical Fellow and Professor of Metabolism and Medicine, University of Cambridge Metabolic Research Laboratories, Cambridge Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 9th January 13:00 - 14:00 Professor Jernej Ule Professor of Molecular Neuroscience, The Francis Crick Institute, Department of Molecular Neuroscience, UCL Institute of Neurology, London Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 16th January 13:00 - 14:00 Professor A.P. Waters Professor of Molecular and Developmental Parasitology, Wellcome Trust Principal Research Fellow, Director, Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 6th February 13:00 - 14:00 Prof. Dr. Rene H. Medema Director of Research, Chairman Board of Directors, The Netherlands Cancer Institute, Amsterdam Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 3rd April 13:00 - 14:00 Professor Matthias Merkenschlager Lymphocyte Development Group, MRC Clinical Sciences Centre, London Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 8th May 13:00 - 14:00 Dr Richard Henderson, FRS Programme Leader, MRC Laboratory of Molecular Biology, Cambridge Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 12th June 13:00 - 14:00 Professor Robin Allshire Professor of Chromosome Biology, Wellcome Trust Centre for Cell Biology, University of Edinburgh Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk

Please visit the Medical Sciences Division seminar page, or our seminar links page for other seminars which may be of interest.

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