Department of Biochemistry University of Oxford Department of Biochemistry
University of Oxford
South Parks Road
Oxford OX1 3QU

Tel: +44 (0)1865 613200
Fax: +44 (0)1865 613201
Image showing the global movement of lipids in a model planar membrane
Matthieu Chavent, Sansom lab
Anaphase bridges in fission yeast cells
Whitby lab
Lactose permease represented using bending cylinders in Bendix software
Caroline Dahl, Sansom lab
Epithelial cells in C. elegans showing a seam cell that failed to undergo cytokinesis
Serena Ding, Woollard lab
Collage of Drosophila third instar larva optic lobe
Lu Yang, Davis lab
First year Biochemistry students at a practical class
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Seminars

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TBA TBA Thursday 29th September 14:00 - 15:00 Gianni Klesse, Joseph Bluck, Bartosz Bartmanski University of Oxford
University of Oxford
University of Oxford
SBCB Seminar Series SBCB seminar Anatomy Lecture Theatre, Le Gros Clark Building, Anatomy Lecture Theatre, off South Parks Road OX1 3QX
anna.duncan@bioch.ox.ac.uk
TBA TBA Monday 3rd October 13:00 - 14:00 Prof Andrew Turberfield (Department of Physics) University of Oxford OUBS Molecular Structures and Machinery from DNA Main seminar room, Biochemistry Building, Main seminar room, off South Parks Road OX1 3QU
By exploiting programmable, sequence-dependent base-pairing interactions it is possible to design and build three-dimensional DNA scaffolds, to attach molecular components to them with sub-nanometre precision and then to make them move. I shall describe our work on autonomous, biomimetic molecular motors powered by chemical fuels, hybrid DNA-kinesin devices, motors that compute, nanostructure assembly, and the use of synthetic molecular machinery to control covalent chemical synthesis.
oubs@bioch.ox.ac.uk
TBA TBA Thursday 6th October 14:00 - 15:00 Prof Phil Biggin University of Oxford SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Friday 7th October 12:00 - 13:00 Davi Bock Janelia Research Campus CNCB Seminar Series Tracing Memory Circuits in Drosophila melaogaster Using Whole-Brain Electron Microscopy Sherrington Library, Sherrington Building, Sherrington Library, off Parks Road OX1 3PT
We imaged the complete brain of a female adult fruit fly at EM resolution. The resulting dataset comprises 21 million images occupying 106 TB. A cluster-backed image processing pipeline was developed to stitch, register, and intensity correct these images, enabling manual tracing of neuronal connectivity throughout the brain. Pilot efforts have focused on the interface between the olfactory system and the mushroom body (MB), the site of associative learning. Each MB contains ~2,000 Kenyon cells (KCs), which receive olfactory input from the antennal lobe via second-order olfactory projection neurons (PNs) in the MB calyx, in what is thought to be a random fashion. KC axons then form a bundle called the pedunculus, which gives rise to the lobes of the mushroom body, where synaptic modulation underlying memory occurs. We traced about 10% of the KCs in the calyx, and their presynaptic PN inputs, to generate a PN-to-KC connectivity graph. We find that KCs that fasciculate with one another in the pedunculus are much more likely to receive input from a common PN, and are also more likely to make axo-axonic synapses with one another. This network structure might be used to sharpen and amplify olfactory signals prior to their arrival in the MB lobes, where synapses are modified during associative Learning.
fiona.woods@cncb.ox.ac.uk
TBA TBA Monday 10th October 13:00 - 14:00 Judy Armitage Biochemistry OUBS Title TBC Main seminar room, Biochemistry Building, Main seminar room, off South Parks Road OX1 3QU
oubs@bioch.ox.ac.uk
TBA TBA Wednesday 12th October 12:00 - 13:00 Robert J Kittel Institute of Physiology, Universitat Wurzburg CNCB Seminar Series Synaptic Vesicle Tethering to the Drosophila Active Zone Cytomatrix Sherrington Library, Sherrington Building,
Bruchpilot (Brp) is a core protein component of the Drosophila active zone (AZ), where it promotes calcium channel clustering to ensure adequate transmitter release. In addition, the C-terminal region of Brp tethers synaptic vesicles to the AZ cytomatrix. In a C-terminally truncated allele, brpnude (lacking the last 17 amino acids), impaired vesicle tethering is accompanied by short-term synaptic depression and impaired sustained transmitter release. We set out to test the hypothesis that neuronal expression of a C-terminal Brp fragment would mimic the synaptic phenotype of brpnude mutants by competitively binding the putative vesicular interaction partner(s) of Brp. Our electrophysiological analysis of larval neuromuscular synapses supports this hypothesis and sets the basis for a subsequent in vivo screen to identify the interacting protein(s). To this end, a membrane-bound C-terminal Brp fragment was neuronally expressed to misdirect synaptic vesicles to ectopic locations. RNAi lines against vesicle-associated proteins were then scored for their ability to revert the ectopic vesicle localisation.
fiona.woods@cncb.ox.ac.uk
TBA TBA Thursday 13th October 14:00 - 15:00 Professor Mark Sansom Department of Biochemistry SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Monday 17th October 13:00 - 14:00 Dr. Dirk Schübeler Senior Group Leader, Friedrich Miescher Institute for Biomedical Research, Basel Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Thursday 20th October 14:00 - 15:00 Dr Phillip Stansfeld University of Oxford SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Monday 24th October 13:00 - 14:00 Prof Mark Howarth University of Oxford Department of Biochemistry OUBS Bacterial superglues to fish for cancer cells and tickle immune cells Main seminar room, Biochemistry Building, Main seminar room, off South Parks Road OX1 3QU
oubs@bioch.ox.ac.uk
TBA TBA Thursday 27th October 14:00 - 15:00 Dr Tyler Reddy University of Oxford SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Monday 31st October 13:00 - 14:00 Professor Jane Mellor University of Oxford OUBS Title TBC Main seminar room, Biochemistry Building, Main seminar room, off South Parks Road OX1 3QU
oubs@bioch.ox.ac.uk
TBA TBA Thursday 3rd November 14:00 - 15:00 Dr Maria Musgaard University of Oxford SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Monday 7th November 13:00 - 14:00 Prof Nicole Zitzmann (Biochemistry) University of Oxford OUBS Title TBC Main seminar room, Biochemistry Building, Main seminar room, off South Parks Road OX1 3QU
oubs@bioch.ox.ac.uk
TBA TBA Thursday 10th November 14:00 - 15:00 George Hedger University of Oxford SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Thursday 10th November 16:00 - 17:00 Joel Mandelstam Lecture Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 14th November 13:00 - 14:00 Prof Jan Rehwinkel (Radcliffe Department of Medicine) University of Oxford OUBS Title TBC Main seminar room, Biochemistry Building, Main seminar room, off South Parks Road OX1 3QU
oubs@bioch.ox.ac.uk
TBA TBA Thursday 17th November 14:00 - 15:00 Marc Daemgen University of Oxford SBCB Seminar Series SBCB seminar Anatomy Lecture Theatre, Le Gros Clark Building, Anatomy Lecture Theatre, off South Parks Road OX1 3QX
anna.duncan@bioch.ox.ac.uk
TBA TBA Monday 21st November 13:00 - 14:00 Professor Neil Brockdorff Department of Biochemistry, University of Oxford OUBS Title TBC Main seminar room, Biochemistry Building, Main seminar room, off South Parks Road OX1 3QU
oubs@bioch.ox.ac.uk
TBA TBA Thursday 24th November 14:00 - 15:00 Dr Matthieu Chavent University of Oxford SBCB Seminar Series SBCB seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Monday 28th November 13:00 - 14:00 Dr Elena Seiradake Department of Biochemistry, University of Oxford OUBS Title TBC Main seminar room, Biochemistry Building, Main seminar room, off South Parks Road OX1 3QU
oubs@bioch.ox.ac.uk
TBA TBA Monday 5th December 13:00 - 14:00 Professor Sadaf Farooqi PhD, FRCP, FMedSci WT Senior Clinical Fellow and Professor of Metabolism and Medicine, University of Cambridge Metabolic Research Laboratories, Cambridge Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 9th January 13:00 - 14:00 Professor Jernej Ule Professor of Molecular Neuroscience, The Francis Crick Institute, Department of Molecular Neuroscience, UCL Institute of Neurology, London Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 16th January 13:00 - 14:00 Professor A.P. Waters Professor of Molecular and Developmental Parasitology, Wellcome Trust Principal Research Fellow, Director, Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 6th February 13:00 - 14:00 Prof. Dr. Rene H. Medema Director of Research, Chairman Board of Directors, The Netherlands Cancer Institute, Amsterdam Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Tuesday 28th February 16:00 - 17:00 Professor Nieng Yan Professor in the School of Medicine at Tsinghua University, Beijing, China Louise Johnson Memorial Lecture Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 3rd April 13:00 - 14:00 Professor Matthias Merkenschlager Lymphocyte Development Group, MRC Clinical Sciences Centre, London Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 8th May 13:00 - 14:00 Dr Richard Henderson, FRS Programme Leader, MRC Laboratory of Molecular Biology, Cambridge Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 12th June 13:00 - 14:00 Professor Robin Allshire Professor of Chromosome Biology, Wellcome Trust Centre for Cell Biology, University of Edinburgh Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 3rd July 13:00 - 14:00 Dr. Arantza Barrios Research Associate, University College London Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk

Please visit the Medical Sciences Division seminar page, or our seminar links page for other seminars which may be of interest.

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