Department of Biochemistry University of Oxford Department of Biochemistry
University of Oxford
South Parks Road
Oxford OX1 3QU

Tel: +44 (0)1865 613200
Fax: +44 (0)1865 613201
Image showing the global movement of lipids in a model planar membrane
Matthieu Chavent, Sansom lab
Anaphase bridges in fission yeast cells
Whitby lab
Lactose permease represented using bending cylinders in Bendix software
Caroline Dahl, Sansom lab
Epithelial cells in C. elegans showing a seam cell that failed to undergo cytokinesis
Serena Ding, Woollard lab
Collage of Drosophila third instar larva optic lobe
Lu Yang, Davis lab
First year Biochemistry students at a practical class
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Seminars

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TBA TBA Wednesday 18th October 12:00 - 13:00 André Fiala University of Göttingen CNCB Seminar Series Learning and Memory in Drosophila: Linking Behavior, Neuronal Circuits and Synaptic Plasticity Centre for Neural Circuits and Behaviour, Tinsley Building, Mansfield Road, Oxford, Tinsley Building, Centre for Neural Circuits and Behaviour, Tinsley Building, Mansfield Road, Oxford, Mansfield Road OX1 3TA
Deciphering how neuronal brain circuits control behaviour represents a key task in modern neuroscience. A fundamental problem is to understand how brains integrate present sensory stimuli, past experience, and behavioural options. We aim at understanding how adaptive behaviour is organized through the properties of single neurons, their synapses, and the circuits the neurons are part of. A combination of genetic tools employing cell-specific transgene expression, e.g., opto- and thermogenetics, splitGFP reconstitution across cells, or functional optical imaging, advances the analysis of brains as integrated systems for the control of behaviour. For such an endeavour, the fruit fly Drosophila melanogaster is particularly suitable. It combines brain simplicity, behavioural richness, and experimental accessibility. We use associative olfactory conditioning paradigms to analyze how odour information is represented in the brain and how odour representations are associated with behavioural relevance through learning. As a model system of how a central brain structure brings about such adaptive behaviour, our research focuses on the mushroom body of the Drosophila central brain. The mushroom body of Drosophila is an evolutionary ancient third-order brain structure, comprising but ~2200 intrinsic neurons. It integrates input from multiple sensory modalities with experience-dependent modulation through multiple biogenic amines and neuropeptides. Its output then is integrated with innate behavioural tendencies to bring about adaptive behaviour. The mushroom body features structural, functional, or cellular similarity with several distinct mammalian brain structures. Our recent research on the function of the mushroom body will be summarized and discussed as a paradigmatic case of how a brain operates.
fiona.woods@cncb.ox.ac.uk
TBA TBA Wednesday 18th October 14:00 - 15:00 Dr James Shorter Associate Professor, Department of Biochemistry and Biophysics, University of Pennsylvania Seminar Reversing aberrant phase transitions of RNA-binding proteins connected to ALS and FTD Seminar Room, Biochemistry Building, Seminar Room, off South Parks Road OX1 3QU
RNA-binding proteins (RBPs) with prion-like domains (PrLDs) phase transition to functional liquids, which can mature into aberrant hydrogels composed of pathological fibrils that underpin fatal neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Several nuclear RBPs with PrLDs including TDP-43, FUS, hnRNPA1, and hnRNPA2 mislocalize to cytoplasmic inclusions in ALS and FTD and mutations in their PrLDs can accelerate fibrillization and cause disease. Here, I will discuss our latest endeavors to uncover and engineer therapeutic protein disaggregases to reverse these aberrant phase transitions and restore functional RBPs to the nucleus to counter ALS and FTD disease phenotypes.
TBA TBA Thursday 19th October 14:00 - 15:00 Prof Phil Biggin University of Oxford SBCB Seminar Series Are simulations predictive? Some recent case studies on iGluRs and Bromodomains Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Thursday 19th October 17:00 - 18:00 Andrew McLean Principal at Oxford Sciences Innovation Seminar Oxford University Biotech Society Seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
info@oxfordbiotech.uk
TBA TBA Friday 20th October 11:00 - 12:00 Juan Bada, Gianni Klesse
University of Oxford
SBMB Seminar Series SBMB Seminars Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
TBA TBA Friday 20th October 12:00 - 13:00 Dr Gaspar Jekely Living Systems Institute, Exeter University CNCB Seminar Series Neural circuits underlying the whole-body coordination of behaviour in Platynereis larvae Lecture Theatre, Oxford Martin School, Lecture Theatre, 34 Broad Street OX1 3BD
Our goal is to understand how neuronal circuits coordinate behaviours extending to whole organ systems or to the entire body. Achieving this at cellular resolution in an entire nervous system is possible by studying small animals amenable to genetic and other manipulations. We are actively developing the marine annelid Platynereis dumerilii as a new system for circuit neuroscience. We use whole-body connectomics, neuronal activity imaging, and behavioural analysis to understand the circuit bases of behaviour in fully mapped, stereotypical circuits. Genome editing and transgenic access to single neurons allow us to link molecular function to network activity and behaviour. I will present recent results on the integration of phototactic and UV-avoidance responses and on a hydrodynamic startle behaviour.
fiona.woods@cncb.ox.ac.uk
TBA TBA Monday 23rd October 11:00 - 12:00 Kevin Foster Microbiology and Systems Biology (MSB) seminars, Department of Biochemistry Cooperation and competition in microbes: from model systems to the microbiome main Seminar room, Biochemistry Building, main Seminar room, off South Parks Road OX1 3QU
TBA TBA Monday 23rd October 13:00 - 14:00 Professor Dame Caroline Dean Project Leader, John Innes Centre, Norwich Biochemistry Department Seminar Antisense transcription and epigenetic switching: lessons from FLC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
How is gene expression quantitatively regulated? Through the study of how plants perceive and respond to winter, we have discovered that Arabidopsis FLC is an excellent system in which to mechanistically dissect how non-coding transcription and chromatin structure quantitatively regulate gene expression. In the warm, an antisense-mediated chromatin mechanism coordinately influences transcriptional initiation and elongation. With increasing cold exposure, FLC is epigenetically silenced through a conserved Polycomb switching mechanism. The talk will describe our latest understanding of this regulation and how it has been modulated during adaptation.
head@bioch.ox.ac.uk
TBA TBA Tuesday 24th October 16:00 - 17:00 Professor Stefan Howorka UCL SynBio.Oxford Building molecular gateways with DNA Seminar room, Biochemistry Building, Seminar room, off South Parks Road OX1 3QU
The Oxford University Society for Synthetic Biology (SynBio.Oxford) is pleased to be hosting a talk by Prof Stefan Howorka (University College London). Prof Howorka is one of the UK's leading synthetic biologists, an expert on the engineering of artificial DNA nanopores and the synthesis of nucleic acid probes. Admission is free, and more details about Prof Howorka's work can be found at: http://www.ucl.ac.uk/chemistry/people/stefan-howorka
TBA TBA Thursday 26th October 14:00 - 15:00 Elizabeth Jefferys University of Oxford SBCB Seminar Series SBCB Seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Friday 27th October 11:00 - 12:00 Joe Bluck, Jo Parker SBMB Seminar Series SBMB Seminars Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
TBA TBA Monday 30th October 11:00 - 12:00 James Wheeler, Florence Wagner Microbiology and Systems Biology (MSB) seminars, Department of Biochemistry Title TBC Main Seminar room, Biochemistry Building, Main Seminar room, off South Parks Road OX1 3QU
TBA TBA Monday 30th October 12:00 - 13:00 Dr Mark Stopfer National Institutes of Health, Bethesda CNCB Seminar Series Neural Codes for the Sense of Taste Lecture Theatre, Oxford Martin School, Lecture Theatre, 34 Broad Street OX1 3BD
Four of the five major sensory systems (vision, olfaction, somatosensation, and audition) are thought to use different but partially overlapping sets of neurons to form unique representations of vast numbers of stimuli. Gustation is considered an exception, by representing only small numbers of basic taste categories. Using new methods for delivering tastant chemicals and making electrophysiological recordings from the gustatory system of the moth Manduca sexta, we found that chemical-specific information is initially encoded in the population of gustatory receptor neurons as broadly distributed spatiotemporal patterns of activity, dramatically integrated and temporally transformed as it propagates to monosynaptically connected second-order neurons, and observed in tastant-specific behavior. Our results suggest that the gustatory system, rather than constructing basic taste categories, uses a spatiotemporal population code to generate unique neural representations of individual tastant chemicals.
fiona.woods@cncb.ox.ac.uk
TBA TBA Monday 30th October 13:00 - 14:00 Dr. Liedewij Laan Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, The Netherlands Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Wednesday 1st November 16:00 - 17:00 Dr Ross Kettleborough Twist Bioscience SynBio.Oxford You design it, we build it! Seminar room, Biochemistry Building, Seminar room, off South Parks Road OX1 3QU
The Oxford University Society for Synthetic Biology (SynBio.Oxford) is pleased to be hosting a talk by Dr Ross Kettleborough (Field Applications Specialist, Twist Bioscience). Dr Kettleborough will be discussing the revolution in DNA synthesis that Twist is driving through their ground-breaking chip technologies. Admission is free, and more details about Twist Bioscience can be found at: https://twistbioscience.com/
TBA TBA Thursday 2nd November 14:00 - 15:00 Dr Phillip Stansfeld University of Oxford SBCB Seminar Series SBCB Seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Friday 3rd November 11:00 - 12:00 Max Epstein, Katharina Jungnickel University of Oxford
SBMB Seminar Series SBMB Seminars Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
TBA TBA Monday 6th November 11:00 - 12:00 Sam Hickman, Stefan Heldt Microbiology and Systems Biology (MSB) seminars, Department of Biochemistry Title TBC Main Seminar room, Biochemistry Building, Main Seminar room, off South Parks Road OX1 3QU
TBA TBA Monday 6th November 13:00 - 14:00 Professor Liz Sockett Faculty of Medical and Health Sciences, Queen's Medical Centre, Nottingham Seminar "Predatory Bdellovibrio bacteria - evolution of predation and application of predators against AMR infections" Lecture Theatre, University Museum of Natural History, Lecture Theatre, Parks Road OX1 3PW
esme.taylor@zoo.ox.ac.uk
TBA TBA Wednesday 8th November 17:00 - 18:00 Mina Bekheet Cofounder and President, Panacea Innovation Seminar Oxford University Biotech Society Seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
info@oxfordbiotech.uk
TBA TBA Thursday 9th November 14:00 - 15:00 Dr Ole Juul Andersen University of Oxford SBCB Seminar Series SBCB Seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Friday 10th November 11:00 - 12:00 Verity Jackson, Felipe Ossa Seraidake Lab
Schnell Group
SBMB Seminar Series SBMB Seminars Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
TBA TBA Tuesday 14th November 16:00 - 17:00 Dr Max Ryadnov National Physicall Laboratory SynBio.Oxford From bottom-up synthetic biology to biometrology Seminar room, Biochemistry Building, Seminar room, off South Parks Road OX1 3QU
The Oxford University Society for Synthetic Biology (SynBio.Oxford) is pleased to be hosting a talk by Dr Max Ryadnov (Principal Research Scientist, National Physical Laboratory). Dr Ryadnov as a distinguished track record of interdisciplinary research and is currently working in a range of areas including synthetic biomaterials, antimicrobial agent discovery and regenerative biology. Admission is free, and more details about Dr Ryadnov can be found at: http://www.npl.co.uk/biotechnology/research/cbm/people/max-ryadnov
TBA TBA Thursday 16th November 14:00 - 15:00 Marc Daemgen University of Oxford SBCB Seminar Series SBCB Seminar Anatomy Lecture Theatre, Le Gros Clark Building, Anatomy Lecture Theatre, off South Parks Road OX1 3QX
anna.duncan@bioch.ox.ac.uk
TBA TBA Friday 17th November 16:00 - 17:00 Dr. Eric Cascales Laboratoire d'Ingenierie des Systemes Macromoleculaires, IBSM, CNRS, France Joel Mandelstam Lecture Structure and Assembly of an antibacterial speargun: the Type VI secretion system Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 20th November 11:00 - 12:00 Hannah Behrens, Jack Dorling Microbiology and Systems Biology (MSB) seminars, Department of Biochemistry Title TBC main Seminar room, Biochemistry Building, main Seminar room, off South Parks Road OX1 3QU
TBA TBA Wednesday 22nd November 16:00 - 17:00 Piers Millett Future of Humanity Institute, University of Oxford SynBio.Oxford Safeguarding synthetic biology: lessons from iGEM Seminar room, Biochemistry Building, Seminar room, off South Parks Road OX1 3QU
The Oxford University Society for Synthetic Biology (SynBio.Oxford) is pleased to be hosting a talk by Dr Piers Millet (Senior Research Fellow, Future of Humanity Institute). Dr Millet has worked for a large number of international organisations including the UN as a world leading expert on issues of biosecurity and the biological weapons convention. He is also the current co-chair of the iGEM competition’s Safety Committee which oversees the security and safety of the work being done by participating teams around the world. Admission is free, and more details about Dr Millett can be found at: https://www.fhi.ox.ac.uk/team/piers-millett/
TBA TBA Thursday 23rd November 14:00 - 15:00 Dr Maria Musgaard University of Oxford SBCB Seminar Series SBCB Seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Thursday 23rd November 17:00 - 18:00 Hagan Bayley Cofounder Oxford Nanopore Technologies Seminar Oxford University Biotech Society Seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
info@oxfordbiotech.uk
TBA TBA Friday 24th November 11:00 - 12:00 Gerard Huysmans SBMB Seminar Series SBMB Seminars Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
TBA TBA Monday 27th November 11:00 - 12:00 Justin Deme, Daniel Unterweger Microbiology and Systems Biology (MSB) seminars, Department of Biochemistry Title TBC Main Seminar room, Biochemistry Building, Main Seminar room, off South Parks Road OX1 3QU
TBA TBA Thursday 30th November 14:00 - 15:00 Dr Wanling Song University of Oxford SBCB Seminar Series SBCB Seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Thursday 30th November 17:00 - 18:00 Matthew Wood Founder Evox Therapeutics Seminar Oxford University Biotech Society Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
info@oxfordbiotech.uk
TBA TBA Friday 1st December 11:00 - 12:00 Henry Sawczyc, Nick Michelarakis SBMB Seminar Series SBMB Seminars Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
TBA TBA Monday 4th December 11:00 - 12:00 Karthik Rajasekar, Oliver Meacock Microbiology and Systems Biology (MSB) seminars, Department of Biochemistry Title TBC MAin Seminar room, Biochemistry Building, MAin Seminar room, off South Parks Road OX1 3QU
TBA TBA Thursday 7th December 14:00 - 15:00 Dr Anna Duncan University of Oxford SBCB Seminar Series SBCB Seminar Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
anna.duncan@bioch.ox.ac.uk
TBA TBA Monday 11th December 11:00 - 12:00 Nicolas Delalez, Mathew Stracy Microbiology and Systems Biology (MSB) seminars, Department of Biochemistry Title TBC Main Seminar room, Biochemistry Building, Main Seminar room, off South Parks Road OX1 3QU
TBA TBA Monday 22nd January 13:00 - 14:00 Professor Jake Baum Professor of Cell Biology and Infectious Diseases, Imperial College London Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 26th February 13:00 - 14:00 Dr. Sjors Scheres Group Leader, MRC Laboratory of Molecular Biology, Cambridge Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 30th April 13:00 - 14:00 Professor Wendy Bickmore, FRS, FMedSci Director: MRC Human Genetics Unit, IGMM, University of Edinburgh Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 11th June 13:00 - 14:00 Professor Steve Jackson, PhD, FRS, FMedSci Frederick James Quick Professor of Biology, The Gurdon Institute, Cambridge Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk
TBA TBA Monday 2nd July 13:00 - 14:00 Professor Stephen Taylor Professor of Cell Biology, The University of Manchester, UK Biochemistry Department Seminar Title TBC Main Seminar Room, Biochemistry Building, Main Seminar Room, off South Parks Road OX1 3QU
head@bioch.ox.ac.uk

Please visit the Medical Sciences Division seminar page, or our seminar links page for other seminars which may be of interest.

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