Examples of students' work
1st Year Practicals
As part of their practical course, 1st year students have to prepare a poster based on one of the laboratory or computer practicals that they have done during the year. The following are some examples of these:
4th Year Research Projects
The majority of the 4th year is an 18 week research project. Students work alongside graduates and postdocs carrying out original research. The results they obtain are often published as part of a wider research program, and occasionally their project will form the entire basis of a publication with the student as first author. The following are some examples:
Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.
E. Norris-Cervetto, R. Callaghan, F.M. Platt, R.A. Dwek and T.D. Butters (2004) J. Biol. Chem., 279, 40412-40418.
Molecular mechanism of sequence-directed DNA loading and translocation by FtsK.
J. Lowe, A. Ellonen, M.D. Allen, C. Atkinson, D.J. Sherratt and I.R. Grainge (2008) Mol. Cell, 31, 498-509.
The C. elegans glycosyltransferase BUS-8 has two distinct and essential roles in epidermal morphogenesis.
F.A. Partridge, A.W. Tearle, M.J. Gravato-Nobre, W.R. Schafer and J.D.J. Hodgkin (2008) Developmental Biology, 317, 549-559.
Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells.
T.D. Butters, D.S. Alonzi, K.V. Kukushkin, Y. Ren and Y. Blériot (2009) Glycoconj. J., 26, 1109-1116.
Uptake and trafficking of liposomes to the endoplasmic reticulum.
S. Pollock, R. Antrobus, L. Newton, B. Kampa, J. Rossa, S. Latham, N. Branza-Nichita, R.A. Dwek and N. Zitzmann (2010) FASEB J., 24, 1866-1878.
Ion mobility mass spectrometry for extracting spectra of N-glycans directly from incubation mixtures following glycan release: Application to glycans from engineered glycoforms of intact, folded HIV gp120.
D.J. Harvey, F. Sobott, M. Crispin, A. Wrobel, C. Bonomelli, S. Vasiljevic, C. Scanlan, C. Scarff, K. Thalassinos and J.H. Scrivens, (2011) J. Am. Soc. Mass Spectrom., 22, 568-58.
ParA-like protein uses nonspecific chromosomal DNA binding to partition protein complexes.
M.A.J. Roberts, G.H. Wadhams, K.A. Hadfield, S. Tickner and J.P. Armitage (2012) Proc. Natl. Acad. Sci. USA, 190, 6698-6703.
Detergent-free incorporation of a seven-transmembrane receptor protein into nanosized bilayer lipodisq particles for functional and biophysical studies.
M. Orwick-Rydmark, J.E. Lovett, A. Graziadei, L. Lindholm, M.R. Hicks and A. Watts (2012) Nano Letters, 12, 4687-4692.
Selective deactivation of serum IgG: A general strategy for the enhancement of monoclonal antibody receptor interactions.
K. Baruah, T.A. Bowden, B.A. Krishna, R.A. Dwek, M. Crispin and C.N. Scanlan (2012) J. Mol. Biol., 420, 1-7.
Multiscale simulations reveal conserved patterns of lipid interactions with aquaporins.
P. J. Stansfeld, E.E. Jefferys and M.S.P. Sansom (2013) Structure, 21, 810-819.
Rab18 and a Rab18 GEF complex are required for normal ER structure.
A. Gerondopoulos, R.N. Bastos, S. Yoshimura, R. Anderson, S. Carpanini, I. Aligianis, M.T. Handley and F.A. Barr (2014) J. Cell Biol., 205, 707-720.
MEMBRANE FUSION A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly.
R.W. Baker, P.D. Jeffrey, M. Zick, B.P. Phillips, W.T. Wickner and F.M. Hughson (2015) Science, 349, 1111-1114.
A conserved amphipathic helix is required for membrane tubule formation by Yop1p.
J.P. Brady, J.K. Claridge, P.G. Smith and J.R. Schnell (2015) Proc. Natl. Acad. Sci. USA, 112, E639-E648.
Starved Escherichia coli preserve reducing power under nitric oxide stress.
G.-O.F. Gowers, J.L. Robinson and M.P. Brynildsen (2016) Biochem. Biophys. Res. Commun., 476, 29-34.
Structural basis for mitotic centrosome assembly in flies.
Z. Feng, A. Caballe, A. Wainman, S. Johnson, A.F.M. Haensele, M.A. Cottee, P.T. Conduit, S.M. Lea and J.W. Raff (2017) Cell, 169, 1078-1089.
Page Last Updated: 05/06/2017 by Dr M. Wormald
© 2017 Department of Biochemistry