Drug Target Interactions
Solid state NMR used as major tool in drug structure determination to sub-nanometer (± 0.03nm) resolution. Drug ligands, such as substituted imidazopyridines in peptic ulcer treatment, acetylcholine in neurological disease treatment (Schizophrenia), and brain neurotensin in treatment of Parkinson's, are all being examined using solid state NMR technology.
Atomic force microscopy (AFM) is being used to visualize conformational changes in membrane receptors upon activation by their ligands. Force measurements made using AFM provide information about binding energies and the selectivity of the ligand - informing the process of rational drug design.
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