Research Section

We take a multidisciplinary approach toward the functional, biophysical and structural analysis of protein-protein interactions in a variety of biological settings.  The figure shows some of the structures of protein complexes we have solved and highlights the range of methods we use to understand how and why proteins form complexes with each other.  Our work is driven by specific biological questions where protein-protein recognition is central to function, and by fundamental questions concerning specificity and affinity of protein-protein interactions.





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