Department of Biochemistry University of Oxford Department of Biochemistry
University of Oxford
South Parks Road
Oxford OX1 3QU

Tel: +44 (0)1865 613200
Fax: +44 (0)1865 613201
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Past and present: Many alumni and current members of the Garman group gather at Elspeth's birthday in September 2014. Back row from left to right: Robin Owen, Robert Southworth-Davies, Jonny Brooks-Bartlett, James Murray, Markus Gerstel. Front row from left to right Charlie Bury, Olga Kuznetsova, Elspeth Garman, Areej AbuHammad, Helen Ginn.

Cecile Royal May 2004

Verane Achard 2006

Dr. Charlie Bury (Oct 2014 - Dec 2017)

 Education: D. Phil student

Charlie's research focused on the development of computational methods (see to track and quantify site-specific damage events in macromolecular structures solved by MX. Charlie applied these high-throughput tools investigate radiation damage to range of protein and nucleic acid systems, and reported the first systematic comparison of radiation damage susceptibilities of protein and nucleic acids for both DNA- and RNA-containing systems. Charlie's research also included a critical re-analysis of MX damage series that were previously deposited in the PDB, in order to revise the mechanism at which tyrosine residues are believed to be damaged.

Dr. Katharina Jungnickel (Sept 2013 - Dec 2017)

 Education: D. Phil student

Kata's research focused on membrane protein structural biology using novel tools such as X-ray free electron lasers (XFEL). Together with Molecular Dimensions Ltd. and supervision by Prof. Elspeth Garman and Dr. Simon Newstead she worked on crystallisation of membrane transporters, development of crystallisation screens and the usage of new techniques in structure determination gaining high resolution data of membrane proteins.



Kathryn Shelley (June 2016 - Sept 2017)

Education: Biochemistry Part II student

Kathryn's research focused on the advances in specific damage detection using Bdamage metric. She completed development of an open-source tool RABDAM to calculate the per-atom Bdamage metric from PDB files, in addition to a highly informative Bnet metric to give an overall indicator for the damage suffered for a PDB entry. She also worked towards the application of energy minimisation methods to correct metal identification in protein crystals.  

Diane Barret (Sept 2016 - July 2017)

 Education: Visiting Masters student

Diane's research involved the investigation of radiation damage to crystalline DNA at both cryo and room temperature. Her research aimed to elucidate why exactly DNA crystals are observed to be so insensitive to radiation damage effects compared to proteins.


Elizabeth Hamilton (Sept 2016 - Mar 2017)

 Education: Biochemistry Part II student

Elizabeth investigated the specific damage sites in a biologically relevant protein (a GH7 family protein) to identify the effects of local environment on damage rates and also the influence of radiation damage on the active site.


Katie Nichols (Sept 2016 - Mar 2017)

 Education: Biochemistry Part II student

Katie's research focused on the applicability of radical scavengers to mitigate radiation damage in room temperature MX. She tested different compounds on their ability to prevent both global and specific damage to test protein systems.


Steve Walsh (Jan 2017 - Apr 2017)

 Education: DTP rotation student

Steve's research involved the implementation of the Compton effect and fluorescent X-ray escape into RADDOSE-3D, in order to provide a more accurate estimate of the absorbed dose during X-ray exposure.


Dr. Jonathan Brooks-Bartlett (October 2013 - December 2016)

 Education: D. Phil student

Jonny's research focused on the development of computational methods to track and mathematically correct for detrimental global radiation damage effects when processing diffraction patterns that are collected during MX data collection. His research was not restricted to MX, and he also studied the effects of radiation damage in SAXS data collection, developing an open source python library 'CorMapAnalysis' to visualise the CorMap (Correlation Map) test results for SAXS data and extending the dose calculation software, RADDOSE-3D, for use in SAXS experiments.


Ben Gayther (June 2016 - September 2016)

 Education: Visiting BSc student (UCL)

Ben worked on implementing a photoelectron escape model into the current version of RADDOSE-3D. When incident X-ray photons interact with a crystal during crystallography experiments, each incident photon has the possibility of interacting via the photoelectric effect and producing a photoelectron. These photoelectrons are still able to move throughout the crystal even at cryo temperatures. In small crystals this effect can be used to reduce the overall radiation damage. If the photoelectron escapes out of the crystal, then the energy of this photon is deposited elsewhere and will therefore not contribute to the radiation dose in the crystal.

Shu Tsukui (March 2015 - August 2015)

 Education: Education: Visiting PhD student (Kyoto University)

Shu investigated the technique of magnetically orientating microcrystals in ultra-light curable resins to create MOMAs (magnetically orientated microcrystal arrays). His research indicated that a combination of MOMAs with conventional synchrotron beamlines could have valuable potential for crystal analyses of protein crystals that do not growto larger sizes.

Rebecca Batters (September 2014 - March 2014)

 Education: Part II student

Rebecca studied the effects of sodium nitrate as a scavenging cryoprotectant for X-ray crystallography experiments to see if it would reduce the structural damage caused by the X-rays during an X-ray crystallography experiment. Further to this Rebecca also studied the different scavenging effects of various scavenger species in small angle X-ray scattering (SAXS) experiments too.

Tom Dixon (September 2014 - March 2014, October 2014 - January 2015)

 Education: Part II student, Research assistant

Tom's research was focussed on quantifying the specific radiation damage to protein molecules in X-ray crystallography experiments. In particular Tom continued work on the B-damage metric, a new metric to developed by Garman group alumnus Markus Gerstel. He adapted the metric to study progressive radiation damage between successive datasets on the same protein structure and also compared how different probing species affects the specific damage observed in protein structures.

Dr. Markus Gerstel (October 2011 - November 2014)

 Education: D. Phil student

Markus made many important contributions to the group during his time here. His research focus was on the specific structural damage that occurs to proteins during an X-ray crystallography experiment. He developed a new mtric called B-damage which allows crystallographers to evaluate the relative damage of each atom in the sample molecule taking into account variable factors such as how densely each atom is packed in the molecule. He also made significant contributions as one of the original authors of the groups dose calculation software RADDOSE-3D. Markus now works at Diamond Light Source and is involved improving data collection and analysis pipelines for crystallographic experiments.

Dr. Helen Ginn (March 2014 - December 2014)

 Education: Wellcome Trust project student

During her time in the group Helen Ginn made key developments in the groups open source dose calculation software RADDOSE-3D. In particular she wrote extensions so that simulations could be performed on crystals of arbitrary shapes, allow users to use PDB codes to define the content of their protein crystals, and translated legacy code into a single language. Helen is now working towards a D. Phil in Dave Stuart's lab developing new computational tools for processing data collected at X-ray free electron lasers (XFELs).

Oliver Starkey (Sept 2013 - March 2014)

 Education: Part II student

Whilst in the group, Oliver worked on Microbeam Proton-Induced X-ray Emission (MicroPIXE). MicroPIXE is a powerful technique that enables identification and quantification of heavy atoms in proteins by using an energetic proton beam to induce characteristic X-rays from these atoms. This complements X-ray crystallography, allowing different metal atoms to be distinguished and more accurately placed in electron density. The main aim of the project was to examine existing metalloproteins in order to validate and/or refine their PDB structures, armed with quantitative data of their metal content. Oliver made ashtonishing discoveries including some that showed that some protein structures that had been deposited in the PDB were deposited with the incorrect metal content.

Dr. Karthik Paithankar (2006 - 2009)

 Education: EU funded postdoctoral fellow on the TotalCryst project

Dr. Oliver B Zeldin 

Education: D. Phil student




Dr. Areej Abuhammed

Education: D.Phil student




John Bembridge

Education: Part II student




Young Choi

Education: Part II student




Dr. Robert Davies

Education: D.Phil student







Elisabeth Armstrong

Education: Part II student







Adam Barker

Education: Part II student








Professor John Fink

Education: BA, University of Iowa 

MS, PhD, University of Michigan

Sabbatical Visiting Maths Professor









Dr. Enrique Rudiño-Piñera

Education: BSc in Chemistry at Universidad La Salle-Mexico 

MSc in Biotechnology-UNAM-Mexico

PhD in Biochemical Sciences at UNAM-Mexico








Dr. James Murray

Education: BA Hons MSci in Natural Science, Emmanuel College Cambridge 

D.Phil in Molecular Biophysics at Worcester College Oxford.




Dr. Robin Owen

Education: MPhys in Physics at Keble College Oxford 

D.Phil in Physics at Keble College Oxford








Dr. Kirsten Leath

Education: MPhys in Physics at the University of St. Andrews 

D.Phil in Biochemistry at the University Oxford






Olga Kuznetsova

Education: Summer student (2008 and 2009) 







François-Xavier Gallat

Education: Summer student (2007) 







Verane Achard

Education: Summer student (2006)









Elodie Loisel

Education: Summer student (2005) 







Cécile Royal

Education: Summer student (2004)











Andrew Gill 

Education: Part II student (2006) 










Melissa Medina 

Education: Part II student (2006) 









Part II students

Tom McDonagh (2007) (summer student)

Andrew Reader (2005)

William Chao (2004) (summer student)

Stephen Betts (2003)

Ben Hall (2002) (summer student)

David Yates (2002)

James Tichler (2002)

James Grimston (2000)

Petra Lukacik (1999)

Dimitri Karathanassis (1999) (summer student)

Paul Tunnah (1995)












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