Department of Biochemistry University of Oxford Department of Biochemistry
University of Oxford
South Parks Road
Oxford OX1 3QU

Tel: +44 (0)1865 613200
Fax: +44 (0)1865 613201
Image showing the global movement of lipids in a model planar membrane
Matthieu Chavent, Sansom lab
Anaphase bridges in fission yeast cells
Whitby lab
Lactose permease represented using bending cylinders in Bendix software
Caroline Dahl, Sansom lab
Epithelial cells in C. elegans showing a seam cell that failed to undergo cytokinesis
Serena Ding, Woollard lab
Collage of Drosophila third instar larva optic lobe
Lu Yang, Davis lab
First year Biochemistry students at a practical class
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Elena Seiradake
Molecular mechanisms in the nervous and vascular systems

Co-workers: Metin Aksu, Onno Akkermans, Celine Zheng, Maria Carrasquero Ordaz and Liam Argent

We study cell guidance receptors involved in brain development, blood vessel formation and cancer. Much like a navigation system, these proteins direct migrating cells and axons through the developing body. This gives rise, for example, to the neural networks that underlie the functions of the brain, and the vascular network that maintains blood flow. In cancers, cell guidance often fails to function properly and as a result cells behave and spread aberrantly. Therefore understanding how guidance receptors work also provides insights into cancer development.

We use a range of powerful and cutting-edge techniques, especially X-ray crystallography, advanced cell biology assays, confocal and super resolution microscopy. Combining multiple techniques allows us to understand how cell guidance receptors function on the molecular, cellular and tissue levels.

Interested in joining the lab? Graduate student and postdoc applications are welcome. Please include: (i) a detailed CV. (ii) official transcripts showing your university grades. (iii) a personal statement + summary of why you wish to join our lab. (iv) the names and contact details of up to three referees. 


Selected recent publications

  1. Jackson VA, Meijer DH, Carrasquero M, van Bezouwen LS, Lowe ED, Kleanthous C, Janssen BJC, Seiradake E. Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction. Nature Communications 2018 Mar 14. doi:10.1038/s41467-018-03460-0
  2. Seiradake E, Jones EY, Klein R. Structural Perspectives on Axon Guidance. Annu Rev Cell Dev Biol. 2016 Oct 6. doi:10.1146/annurev-cellbio-111315-125008
  3. Jackson VA, Mehmood S, Chavent M, Roversi P, Carrasquero M, del Toro D, Seyit-Bremer G, Ranaivoson FM, Comoletti D, Sansom MSP, Robinson CV, Klein R, Seiradake E. Super-complexes of adhesion GPCRs and neural guidance receptors. Nature Communications 2016 Apr 19 doi:10.1038/ncomms11184
  4. Jackson VA, del Toro D, Carrasquero M, Roversi P, Harlos K, Klein R, Seiradake E. Structural basis of Latrophilin-FLRT interaction. Structure 2015 Apr 7;23(4):774-81. 
  5. Seiradake E, del Toro D, Nagel D, Cop F, Haertl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R. FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development. Neuron 2014 Oct 22;84(2):370-85.
  6. Kaufmann R, Schellenberger P, Seiradake E, Dobbie IM, Jones EY, Davis I, Hagen C, Grunewald K. Super-resolution microscopy using standard fluorescent proteins in intact cells under cryo-conditions. Nano Lett. 2014 Jul 9;14(7):4171-5.
  7. Seiradake E, Schaupp A, del Torro Ruiz D, Kaufmann R, Mitakidis N, Harlos K, Aricescu AR, Klein R, Jones EY. Structurally encoded intraclass differences in EphA clusters drive distinct cell responses. Nature Struct Mol Biol 2013 Aug;20(8):958-64.
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