The Department has some of the best-equipped facilities in the country, supporting researchers in a number of areas including biophysics, high-resolution microscopy, NMR, protein crystallisation and proteomics.
Our equipment is available to researchers in Biochemistry and other departments within the University, and also to those working in industry. The Molecular Biophysics Suite, for example, provides an important service to local biotech and pharma companies who benefit from both the infrastructure and technical expertise offered.
The service and expertise we provide is tailored to suit the needs of users. Formal training courses or informal one-to-one training is offered for a number of the facilities including the Molecular Biophysics Suite, Micron and NMR.
For general enquiries about the facilities and to discuss your needs in more details, please contact us (email@example.com or 01865 613328). Details about the equipment and its use can be found below, under the individual facility.
The Department also has strong links to many other facilities within the University and more widely in the area. These include:
- Electron Microscopy (at STRUBI and the Dunn School)
- Drug Discovery Oxford
- OxSynC (provides expertise in synthetic chemistry)
- Diamond Light Source and ISIS neutron source (Harwell)
- Research Complex at Harwell (OPPF-UK, Central Laser Facility)
Comprehensive information about research equipment and facilities available across the University, some of which is restricted to internal users, can be found here.
Molecular Biophysics Suite
We offer a range of techniques to study macromolecules and macromolecular complexes. These include analytical ultracentrifugation, differential scanning calorimetry, electrospray ionization mass spectrometry, isothermal titration calorimetry and surface plasmon resonance. All users must be registered with Dr David Staunton and receive any necessary training.
Contact – Dr David Staunton (firstname.lastname@example.org; 01865 (6)13328)
Further information -
Micron Oxford Advanced Bioimaging Unit
Micron Oxford is a multidisciplinary unit focusing on the development and use of single molecule methods, light sheet and super-resolution microscopy. It is located within the Department of Biochemistry and the Dunn School of Pathology.
Contact – email@example.com
Further information - http://www.micron.ox.ac.uk/microngroup/home.php
The NMR facility houses four solution-state spectrometers operating at 1H frequencies of 500, 600, 750 and 950 MHz. The 500 and 600 MHz spectrometers have Bruker consoles with triple-resonance TCI Cryoprobes. The facility is located in the basement of the Rex Richards Building close to the New Biochemistry building. All users must be registered and trained to use the facility.
Contact – Professor Christina Redfield (firstname.lastname@example.org; 01865 (2)75330)
Further information - http://www.bioch.ox.ac.uk/aspsite/index.asp?sectionid=nmrfacility
The Crystallisation Facility houses robotic systems for high throughput macromolecular crystallisation and gives users access to a broad range of crystallisation screens, additives and visualisation instruments. The robotic instruments include:
- TTP Mosquito for the preparation of crystallisation trials.
- ArtRobbins LCP Gryphon for the preparation of lipidic cubic phase crystal trials.
- Rigaku Minstrel HTUV crystallisation imager with integrated robotic imagers, allowing the storage and automatic imaging of crystals at 4C or 18C using both visible and UV light for visualisation.
The facility also contains a variety of microscopes for the visualisation and harvesting of crystals, cold room facilities, and capacity for the storage of cryo-cooled crystalline samples.
The facility manager, Dr Ed Lowe, can offer assistance with both the preparation of crystallisation trials and with the processing of data following diffraction experiments.
Contact – Dr Ed Lowe (email@example.com; 01865 (6)13288)
(internal users can find out more on the crystallisation facility wiki)
Advanced Proteomics Facility
We provide access to cutting edge mass spectrometry and have experience in protein identification, quantitative mass spectrometry, and characterisation methods for a range of post-translational modifications. Our facility is equipped with a wide range of instrumentation, sample preparation technologies and data analysis software.
Please always contact us prior to commencing a new project in order to discuss project aims and requirements.
The main facility website is available here.
Flow Cytometry Facilities:
A Becton and Dickenson 3-colour flow cytometer (FACScalibur) is available, which has cell sorting ability. Based in Rodney Porter Building, 20.25 Containment Level 2. More Details