Department of Biochemistry University of Oxford Department of Biochemistry
University of Oxford
South Parks Road
Oxford OX1 3QU

Tel: +44 (0)1865 613200
Fax: +44 (0)1865 613201
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Hans Krebs Tower demolition underway
Photo: Jeremy Rowntree The start of the demolition of the Hans Krebs Tower has been marked by a ceremony on August 18th. Published: 21 August 2014
Anthony Watts wins prestigious BPS award
Professor Anthony Watts Professor Anthony Watts is to receive the 2015 Anatrace Membrane Protein Award of the Biophysical Society. Published: 21 August 2014
Rob Klose wins prestigious Royal Society award
Rob Klose Rob Klose has been awarded the 2015 Francis Crick Lecture for his work on understanding how chromatin-based and epigenetic processes contribute to gene regulation Published: 5 August 2014

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Athena Swan Bronze Award

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Welcome

The Department of Biochemistry

Welcome to the Department of Biochemistry, part of the University of Oxford's Medical Sciences Division. We are one of the largest Biochemistry departments in the world and carry out world-class research and teaching. Our researchers come from a range of disciplines and work in a collaborative environment on all aspects of modern molecular and cellular biochemistry. We hope you enjoy reading more about our activities on these pages.

Professor Mark Sansom, Head of Department

News Highlight

Malarial invasion protein yields structural clues for vaccine development

A group of Oxford researchers has revealed promising new findings about a protein necessary for invasion of red blood cells by malarial parasites.

The structure of PfRH5: two views of the protein construct used for crystallisation studies, coloured as a rainbow from blue (N terminus) to red (C terminus)

The structure of PfRH5: two views of the protein construct used for crystallisation studies, coloured as a rainbow from blue (N terminus) to red (C terminus) (Click to enlarge)

The work from Dr Matt Higgins' lab in the department in collaboration with Dr Simon Draper at the Jenner Institute is published in Nature (1).

It describes the structure of Plasmodium falciparum RH5, the only malarial protein so far shown to be essential in the invasion process, and its interaction with host protein, basigin.

By targeting one of the best vaccine candidates for malaria, the work opens the door for the development of a new generation of vaccines against this deadly disease.

The RH5 protein belongs to one of two protein families that are important for the invasion process. Reticulocyte-binding protein homologue (RH) proteins are found in all Plasmodium species, but only RH5 from Plasmodium falciparum (PfRH5) has been shown to be essential in the invasion process in all tested strains.

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Seminars

SBCB Seminar Series Dr. Rilei Yu, 'Conformation and function of the Cys-loop receptors: Insight from MD simulations' Thursday 28th Aug, 14:00 Main Meeting Room, New Biochemistry Building
Departmental Seminar Prof. Jibak LEE, 'Potential roles of condensins during mouse oocyte maturation and early embryogenesis' Friday 5th Sep, 15:30 Main Meeting Room, New Biochemistry Building
Departmental Seminar Prof.Tomoya KITAJIMA, 'Major causes of chromosome segregation errors during meiosis in mouse oocytes' Friday 5th Sep, 16:00 Main Meeting Room, New Biochemistry Building
SBCB Seminar Series Eiji Yamamoto, 'Anomalous dynamics of pleckstrin homology domains on a lipid membrane surface' Thursday 9th Oct, 14:00 Main Meeting Room, New Biochemistry Building


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