Department of Biochemistry University of Oxford Department of Biochemistry
University of Oxford
South Parks Road
Oxford OX1 3QU

Tel: +44 (0)1865 613200
Fax: +44 (0)1865 613201
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News

London art exhibition features cell cycle research from the Nasmyth lab
Mouse myoblast cell in late stage of cell division. Credit: Lothar Schermelleh A new exhibition at Central Saint Martins will illuminate the hidden world of mitosis being revealed by the cross-European MitoSys project Published: 21 January 2015
Department wins prestigious BBSRC strategic grant for cell cycle work
A mammalian cell undergoing cell division, with DNA in blue and microtubules in red Biochemistry researchers Bela Novak and Francis Barr, together with colleagues in Oxford, London and the University of Sussex, have won 3m for a BBSRC Strategic LoLa grant. Published: 14 January 2015
Latest Publications
Read about some of the latest publications to come from the Department. Published: 8 January 2015

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Athena Swan Bronze Award

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Welcome

The Department of Biochemistry

Welcome to the Department of Biochemistry, part of the University of Oxford's Medical Sciences Division. We are one of the largest Biochemistry departments in the world and carry out world-class research and teaching. Our researchers come from a range of disciplines and work in a collaborative environment on all aspects of modern molecular and cellular biochemistry. We hope you enjoy reading more about our activities on these pages.

Professor Mark Sansom, Head of Department

News Highlight

Dynamic behaviour of bacterial injectisome component visualised in new study

Schematic of the bacterial Type III secretion injectisome which injects effector proteins directly into the host cell. The C-ring cytosolic component is shown in red

Schematic of the bacterial Type III secretion injectisome which injects effector proteins directly into the host cell. The C-ring cytosolic component is shown in red

Research in the department has shed light on a machinery that causes virulence in a group of pathogenic bacteria.

The work from Professor Judy Armitage's lab, led by Dr Andreas Diepold, reveals previously unobserved features of the injectisome, an essential virulence factor that is responsible for the transmission of bacterial proteins into host cells.

Published in PLoS Biology with collaborators from the Department of Physics in Oxford and the Biozentrum in Basel, the findings suggest the possibility of a novel target for the development of anti-virulence drugs (1).

Many Gram-negative bacteria such as Shigella, Salmonella and Yersinia use the Type III secretion system to help them to thrive in their host. The machinery, also called injectisome, uses a protruding needle to inject a range of effector molecules into host cells, allowing the bacteria to proliferate without being eliminated by the host immune system.

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Seminars

Departmental Seminar Hugh Dannatt (Watts group), 'LMB seminar' Friday 6th Feb, 11:00 Main Meeting Room, New Biochemistry Building
LMB Seminars Katarina Jansen (Kleanthous group), 'LMB seminar: Modelling regulation of ligand-gated ion channelsStructural insights into β-barrel assembly machinery that is responsible for outer membrane protein biogenesis' Friday 13th Feb, 11:00 Main Meeting Room, New Biochemistry Building
SBCB Seminar Series Dr. Teresa Paramo, 'Simulation and modelling approaches to allosteric regulation' Thursday 19th Feb, 14:00 Main Meeting Room, New Biochemistry Building
Departmental Seminar Dirk Reiter (Vakonakis group), 'LMB seminar' Friday 20th Feb, 11:00 Main Meeting Room, New Biochemistry Building


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