Department of Biochemistry University of Oxford Department of Biochemistry
University of Oxford
South Parks Road
Oxford OX1 3QU

Tel: +44 (0)1865 613200
Fax: +44 (0)1865 613201
Collage of Drosophila third instar larva optic lobe
Lu Yang, Davis lab
First year Biochemistry students at a practical class
Image showing the global movement of lipids in a model planar membrane
Matthieu Chavent, Sansom lab
Anaphase bridges in fission yeast cells
Whitby lab
Lactose permease represented using bending cylinders in Bendix software
Caroline Dahl, Sansom lab
Epithelial cells in C. elegans showing a seam cell that failed to undergo cytokinesis
Serena Ding, Woollard lab
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Water-bridging as an essential component for initiating protein folding
Showing the water bridge in KGPGK A recent publication in the Journal of the American Chemical Society from research performed in the McLain Group from DPhil student Nicola Steinke, has focused on investigating the roles that both water and the primary amino acid sequence have in initiating -turn formation in solution Published: 1 June 2018
Patryk Ludzia wins a Boehringer Ingelheim Fonds PhD fellowship
Alt Text Patryk Ludzia, a DPhil student in Bungo Akiyoshi's group, has been awarded a prestigious Boehringer Ingelheim Fonds PhD fellowship. The fellowship is awarded to outstanding junior scientists who wish to pursue an ambitious PhD project in basic biomedical research in an internationally leading laboratory Published: 6 August 2018
Prof Judith Armitage elected next President of The Microbiology Society
Prof Judith Armitage Professor Judith Armitage has been elected the next President of The Microbiology Society. She will take up the 3 year office in January 2019. Published: 16 July 2018
Don't sweat it: Scientists identify key step in production of BO
Associate Professor Simon Newstead Researchers have unravelled a key part of the molecular process by which armpit bacteria produce the most pungent component of the noxious smell we recognise as BO. The findings could result in more effective deodorants with targeted active ingredients, the researchers suggest Published: 5 July 2018
2018 Sosei Heptares Prize for Biophysics to be awarded to Prof Elspeth Garman
Professor Elspeth Garman The recipient of the 2018 Sosei Heptares Prize for Biophysics has been announced as Professor Elspeth Garman, Department of Biochemistry, University of Oxford. Published: 2 July 2018

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Mark Sansom, Head of Department

The Department of Biochemistry at the University of Oxford is a centre for world class research and teaching of all aspects of Biochemistry by staff from many different backgrounds and nationalities. Our research addresses a wide range of questions relating to the fundamental basis of all cellular life from man to microbes. This work explains the structures and functions of proteins and nucleic acids, and in doing so addresses the mechanisms of many human diseases. Using this knowledge, other researchers aim to create new vaccines, antiviral and antibacterial therapies to protect and treat humans across the world.

You can read more about the details of our current work and other aspects of the department, including undergraduate teaching and public outreach activities, on these web pages.

Professor Mark Sansom, Head of Department

News Highlight

A Summer of Simulations

Three recent papers from the Sansom group reveal how molecular simulations can complement experimental studies in advancing our understanding of membrane protein interactions underlying membrane organization and function.

Collaborative research with Carol Robinson’s group (Chemistry) employs molecular simulations to aid the design and interpretation of mass spectrometry-based experiments. The study, published in Nature, uncovers a new role for phosphatidylinositol 4,5-bisphosphate (PIP2) lipids in the modulation of signalling by G-Protein Coupled Receptors

As part of an ongoing collaboration with Yvonne Jones’ group in STRUBI, Chavent et al use simulations to reveal interactions of the EphA2 receptor tyrosine kinase with the intracellular surface of a model cell membrane. The study, published in Structure, shows how phosphatidylinositol phosphates (PIPs) mediate interaction of the EphA2 kinase domain with the membrane, whilst kinase and juxta-membrane domains induce formation of nanoclusters of PIP molecules. These results enable computational reconstitution of a near complete EphA2 receptor model.  

Image Caption

Figure 1: Snapshots from a coarse-grained MD (left) and from a mesoscale (right) simulation of bacterial outer membrane protein clustering.

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Keep in touch with the Department


SBCB Seminar Series Laura John, 'SBCB seminar' Thursday 6th Sep, 14:00 Main Seminar Room, New Biochemistry Building
SBCB Seminar Series William Glass, 'SBCB seminar' Thursday 13th Sep, 14:00 Main Seminar Room, New Biochemistry Building
SBCB Seminar Series Joseph Bluck, 'SBCB seminar' Thursday 20th Sep, 14:00 Main Seminar Room, New Biochemistry Building
Departmental Seminar Dr Maria Harkiolaki, 'Correlative soft-X ray cryo-tomography and super resolution fluorescence microscopy imaging for the life sciences at Diamond Light Source beamline B24.' Friday 21st Sep, 13:00 Seminar Room, New Biochemistry Building

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Athena Swan Silver Award