Department of Biochemistry University of Oxford Department of Biochemistry
University of Oxford
South Parks Road
Oxford OX1 3QU

Tel: +44 (0)1865 613200
Fax: +44 (0)1865 613201
Collage of Drosophila third instar larva optic lobe
Lu Yang, Davis lab
First year Biochemistry students at a practical class
Image showing the global movement of lipids in a model planar membrane
Matthieu Chavent, Sansom lab
Anaphase bridges in fission yeast cells
Whitby lab
Lactose permease represented using bending cylinders in Bendix software
Caroline Dahl, Sansom lab
Epithelial cells in C. elegans showing a seam cell that failed to undergo cytokinesis
Serena Ding, Woollard lab
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News

Dr Tim Nott awarded Wellcome Trust Sir Henry Dale Fellowship
Dr Tim Nott Dr Tim Nott has been awarded the prestigious Sir Henry Dale Fellowship from the Wellcome Trust, for his research into the emerging area of membraneless organelles Published: 16 June 2016
Matthieu Chavent receives PRACEdays16 Award
PRACEdays16 Dr. Matthieu Chavent recently received the PRACEdays16 Award for Best Scientific Presentation for his talk entitled "Membrane Protein Crowding: filling the gap between computations and experiments" Published: 19 May 2016

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Athena Swan Bronze Award

Vacancies

There are eight job vacancies available

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Welcome

Mark Sansom, Head of Department

Welcome to the Department of Biochemistry, part of the University of Oxford's Medical Sciences Division. We are one of the largest Biochemistry departments in the world and carry out world-class research and teaching. Our researchers come from a range of disciplines and work in a collaborative environment on all aspects of modern molecular and cellular biochemistry. We hope you enjoy reading more about our activities on these pages.

Professor Mark Sansom, Head of Department

News Highlight

Wellcome News for Protein Antibiotics

Protein antibiotics are able to kill biofilms such as that shown in the figure for P. aeruginosa. Biofilms are often insensitive to traditional antibiotics (Click to enlarge)

The inexorable rise of antibiotic resistant bacteria threatens to cast our society back to the days before Alexander Fleming's discovery of penicillin. Some of the most problematic of these multidrug resistant microbes are Gram-negative bacteria which, because of their additional outer membrane, are not susceptible to antibiotics that are active against Gram-positive bacteria. The Wellcome Trust has recently funded a collaborative award for the development of a new class of antibiotics, based on proteins that specifically kill Gram-negative bacteria. Spearheaded by Colin Kleanthous in Oxford and Dan Walker in Glasgow, and including colleagues in Oxford, Glasgow, London and the Sanger Institute in Cambridge, the new funding will focus on protein toxins known as bacteriocins. Protein bacteriocins are species-specific antimicrobials that are normally produced by Gram-negative bacteria to kill competitors. The WT-funded consortium will investigate the effectiveness of such protein antibiotics on multidrug resistant Pseudomonas aeruginosa and Klebsiella pneumoniae, which pose huge problems in hospitals around the world. Both organisms cause life-threatening lung and blood infections in infants and immunocompromised patients, and have seen alarming rises in multidrug resistance. Recent estimates from the World Health Organisation suggest that more than 50% of P. aeruginosa isolates-the leading cause of mortality in cystic fibrosis patients-are resistant to the most commonly used antibiotics and alarmingly, often resistant even to the antibiotics of last resort.

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Seminars

Biochemistry Department Seminar Professor Haruhiko Koseki, 'The PCGF6-PRC1 complex suppresses premature activation of meiosis and germ cell related genes in ES cells' Tuesday 28th Jun, 11:00 Seminar Room, New Biochemistry Building
SBCB Seminar Series Qinrui Wang, Susan Leung, 'SBCB seminar' Wednesday 29th Jun, 14:00 Main Seminar Room, New Biochemistry Building
Special Seminar Dr. Benjamin Rowland, 'Chromosome organization by SMC complexes: linking sisters and extruding loops”' Friday 1st Jul, 14:30 Main Seminar Room, New Biochemistry Building
OUBS Prof. Dr. Matthias Mann, 'Lunch for students doing a Dphil in Biochemistry with Prof Dr Matthias Mann' Tuesday 5th Jul, 13:00 Meeting Room TBA, New Biochemistry Building


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