studentships

Department of Biochemistry Postgraduate Studentships

 

In collaboration with the Medical Sciences Division and Colleges, the Department awards a number of Postgraduate Research Studentships each year. These are full awards that will cover University and College Fees and funding for living expenses. All applicants that apply by the early January deadline will automatically be considered for one of these awards.

 

Group Leader and Project-specific Studentships

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Department of Biochemistry, University of Oxford

Main academic supervisor: Prof. Elena Seiradake

Please quote Studentship Source Code: ELA1

PROJECT DESCRIPTION

Background. 'Cell guidance receptors' are specialised proteins that are found at the surfaces of cells. They direct the formation of complex tissues such as the neural and vascular networks. Understanding how these tissues form is important, because failure leads to developmental diseases and cancers. The lab uses a range of cutting-edge techniques, especially X-ray crystallography, electron microscopy, cell biology assays, confocal and super-resolution microscopy. Combining these techniques allows us to understand how cell guidance receptors function on the molecular, cellular and tissue levels. This DPhil project focuses on the distinct and emerging class of adhesion G-protein-coupled receptors (adhesion GPCRs). These contain large extracellular domains that mediate cell-cell and cell-matrix interactions. How these receptors are implicated in human diseases is not well understood, hampering progress in treating the associated diseases.

Project. Your research will aim to discover how adhesion GPCRs function in brain development. The project involves X-ray crystallography and cryo-electron microscopy to determine the structures of adhesion GPCRs and their binding partners, and/or cell biology combined with advanced fluorescence microscopy to investigate how they direct cells. The results will underpin the development of new drugs and treatments for neurodevelopmental disorders and cancers. We will provide training in the required areas, such as protein expression and purification from large-scale mammalian expression systems, biophysical analysis, mammalian cell culture, and use of the microscopy and biophysical facilities at Oxford and Harwell. There will also be opportunities for collaboration involving molecular modelling, mass spectrometry and specialised experiments to study protein function in situ.

Further information and background reading: http://seiradake.web.ox.ac.uk

Eligibility: we welcome applications from UK and EU applicants.

Students with a molecular biology, cell biology or biochemistry background, ideally with some relevant practical undergraduate experience, would be preferred.

The project is supported by a 3-year PhD studentship covering fees (at the Home/EU rate) plus a living cost allowance of not less than £14,777 per annum. The successful applicant will become a member of Somerville College.

To apply for this funded studentship, please submit an online application to the University of Oxford for admission to the D.Phil. in Biochemistry (course code: RD_BC1) by the deadline 12.00 noon (UK time) 15th February 2019.  It is very important that you quote Studentship Source Code ELA1. No research proposal is required as part of the application. Instead you are required to upload a personal statement of no more than 1000 words, describing your motivation and aptitude for this position, and your CV, plus official transcripts of your undergraduate marks and degrees. Please arrange that three referees directly submit references for you.

Department of Biochemistry, University of Oxford

Main academic supervisors: Professors Andre Furger and Jane Mellor

Please quote Studentship Source Code: Perci1

PROJECT DESCRIPTION

The main aim of our research is to understand how cells reprogram and adapt their gene expression in response to specific cues including biotic and abiotic stresses and during disease progression. The available DPhil project is focussing on the question of how cells adapt to sub-physiological temperatures which human cells can experience during a number of medical procedures such a cold cardioplegia and during transplant organ preservation. Whilst we have a good understanding of the processes and pathways that are activated when cells experience heat shock, we know very little about how cells adapt when they experience very low temperatures.

The project aims to address this issues. We want to understand how particular cellular pathways are activated by cold stress and determine the underlying molecular mechanisms. We have already identified a number of highly interesting genes that are activated human cardiomyocytes in response to cold shock and the successful candidate will continue to elucidate these exciting new leads.

Training Opportunities:

The successful candidate will be based in the department of Biochemistry where we have state of the art facilities and provide training opportunities in a wide range of techniques and instruments. These include training on the Ion Proton sequencing platform, training in bioinformatics, high-resolution cell imaging, cell culture, RNAseg, Netseg and classic moleculor biology techniques and gene editing approaches. The successful candidate will be supervised by Professor Andre Furger and Professor Jane Mellor.

The Scholarship

The scholarship covers course fees (at Home/EU rate) and a grant for £14,777. Awards are made for the full duration of your fee liability for the agreed course. The scholarship is jointly funded by the University and a generous endowment from Percival Stanion, an alumnus of Pembroke College where he was an undergraduate in the 1970s, and a member of the Pembroke Master's Circle as well as of its Investment Committee.

Further information and background reading:

Group website: http://www.bioch.ox.ac.uk/research/furger

Students with a molecular biology, cell biology or biochemistry background, ideally with some relevatn practical undergraduate experience, would be preferred. Informatal enquiries are welcome : andre.furger@bioch.ox.ac.uk

To apply for this funded studentship, please submit an online application to the University of Oxford for admission to the D.Phil. in Biochemistry (course code: RD_BC1) by the deadline 12.noon (UK time) 11th January 2019. It is important that you quote Studentship Source Code Perci1. No research proposal is required as part of the application. Instead you are requried to upload a personal statement of no more than 1000 words, describing your motivation and aptitude for this position, and your CV, plus including official transcripts of your undergraduate marks and degrees. Please arrange that three referees directly submit references for you.

Wolfson College is offering jointly with the Department of Biochemistry a fully-funded three year graduate Scholarship for a DPhil student to be held at the University of Oxford from the beginning of the academic year 2019-2020. 

Applications are invited from suitably qualified graduates who are applying for entry to the DPhil in Biochemistry programme in October 2019. The Scholarship is awarded on the basis of academic merit and potential. 

The Scholarship is open to all students and will cover the full cost of a home/EU award including the course fees and maintenance costs at the current UK Research Council rate. The successful scholar will become a member of Wolfson College. 

There is no separate application process. Applicants should apply to the University of Oxford’s DPhil in Biochemistry programme by the deadline on Friday 11th January 2019 (for details please see: https://www.ox.ac.uk/admissions/graduate/courses/dphil-biochemistry?wssl=1). If there are two or more candidates of equal academic merit, priority will be given to the candidate who has listed Wolfson as his or her first choice college on the University application form.

The Oxford Wolfson Marriott Scholarships have been made possible by a donation to Wolfson College from the late Dr Francis Marriott, who was a University Lecturer and Fellow of Wolfson from 1970 to his death in 2012. Dr Marriott conducted research in the field of biomathematics, and taught statistics.

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