Department of Biochemistry, University of Oxford
Main academic supervisors: Professors Andre Furger and Jane Mellor
Please quote Studentship Source Code: Perci1
The main aim of our research is to understand how cells reprogram and adapt their gene expression in response to specific cues including biotic and abiotic stresses and during disease progression. The available DPhil project is focussing on the question of how cells adapt to sub-physiological temperatures which human cells can experience during a number of medical procedures such a cold cardioplegia and during transplant organ preservation. Whilst we have a good understanding of the processes and pathways that are activated when cells experience heat shock, we know very little about how cells adapt when they experience very low temperatures.
The project aims to address this issues. We want to understand how particular cellular pathways are activated by cold stress and determine the underlying molecular mechanisms. We have already identified a number of highly interesting genes that are activated human cardiomyocytes in response to cold shock and the successful candidate will continue to elucidate these exciting new leads.
The successful candidate will be based in the department of Biochemistry where we have state of the art facilities and provide training opportunities in a wide range of techniques and instruments. These include training on the Ion Proton sequencing platform, training in bioinformatics, high-resolution cell imaging, cell culture, RNAseg, Netseg and classic moleculor biology techniques and gene editing approaches. The successful candidate will be supervised by Professor Andre Furger and Professor Jane Mellor.
The scholarship covers course fees (at Home/EU rate) and a grant for £14,777. Awards are made for the full duration of your fee liability for the agreed course. The scholarship is jointly funded by the University and a generous endowment from Percival Stanion, an alumnus of Pembroke College where he was an undergraduate in the 1970s, and a member of the Pembroke Master's Circle as well as of its Investment Committee.
Further information and background reading:
Group website: http://www.bioch.ox.ac.uk/research/furger
Students with a molecular biology, cell biology or biochemistry background, ideally with some relevatn practical undergraduate experience, would be preferred. Informatal enquiries are welcome : email@example.com
To apply for this funded studentship, please submit an online application to the University of Oxford for admission to the D.Phil. in Biochemistry (course code: RD_BC1) by the deadline 12.noon (UK time) 11th January 2019. It is important that you quote Studentship Source Code Perci1. No research proposal is required as part of the application. Instead you are requried to upload a personal statement of no more than 1000 words, describing your motivation and aptitude for this position, and your CV, plus including official transcripts of your undergraduate marks and degrees. Please arrange that three referees directly submit references for you.