Dr João Monteiro

Dr João Monteiro

Host-pathogen dynamics in phagocytosis

Bacteria are highly adaptable organisms that deploy a wide range of defensive and offensive strategies to colonise diverse environments. Some of the most dangerous pathogens can evade killing by host immune cells and establish intracellular niches that shield them from antibiotics and host attack. Infected “Trojan horse” cells act as reservoirs and drive pathogens to new infection sites, contributing to chronic and relapsing disease.

Research Focus 
How do some bacteria survive the inhospitable environment of the host? 
The Monteiro lab takes a dual approach to study intracellular infection. On the pathogen side, we examine how bacteria regulate cell cycle progression, growth and division within host cells, and the molecular mechanisms that protect them from stress. On the host side, we investigate cellular pathways that control the rate and efficiency of phagocytosis and bacterial clearance. Our goal is to identify vulnerabilities and to test antimicrobial/immunomodulatory strategies for treatment.

Our Approach
We use our state-of-the-art super resolution microscopes to investigate a range of host-pathogen dynamics during intracellular infection. We integrate this with molecular and cell biology, RNA-seq, proteomics, gene editing, protein modelling and therapeutics testing to build a mechanistic understanding of phagocytosis. 

Joining the lab
We welcome enquiries from motivated students and researchers with an interest in host–pathogen interactions, cell biology or super-resolution microscopy. 
We encourage postdocs to contact us regarding fellowship applications. PhD students please apply through relevant Oxford University doctoral programs. Undergraduate students interested in developing Part II or research projects in the lab are also welcome.