Advanced Proteomics Facility

The Advanced Proteomics Facility provides access to the latest proteomics technologies. We can accommodate simple requests such as protein identification all the way up to generation of temporal profiles of entire proteomes and common post translational modifications.

The Advanced Proteomics Facility provides access to the latest proteomics technologies. We can accommodate simple requests such as protein identification all the way up to generation of temporal profiles of entire proteomes and common post translational modifications.

The Advanced Proteomics Facility provides access to the latest proteomics technologies. We can accommodate simple requests such as protein identification all the way up to generation of temporal profiles of entire proteomes and common post translational modifications.

The Advanced Proteomics Facility provides access to the latest proteomics technologies. We can accommodate simple requests such as protein identification all the way up to generation of temporal profiles of entire proteomes and common post translational modifications.

The Advanced Proteomics Facility provides access to the latest proteomics technologies. We can accommodate simple requests such as protein identification all the way up to generation of temporal profiles of entire proteomes and common post translational modifications.

The Advanced Proteomics Facility provides access to the latest proteomics technologies. We can accommodate simple requests such as protein identification all the way up to generation of temporal profiles of entire proteomes and common post translational modifications.

The APF team have expertise in sample preparation, protein chemistry, mass spectrometry and bioinformatics. The facility is equipped with a wide range of mass spectrometry instrumentation, HPLC fractionation systems, sample preparation technologies and data analysis software. We provide protein, protein complex, proteome identification as routine services. Often once identified the questions switch to how much is there and how is it regulated? So, we also have extensive experience in quantitative mass spectrometry and characterisation methods for a range of post-translational modifications, which aid regulation, such as phosphorylation, methylation and ubiquitylation. The facility is also carrying out research and is constantly evolving introducing new technologies and services.

We can handle all the steps in an experiment from protein extraction out of a cell pellet/tissue biopsy to data analysis. However, we do encourage all to perform their own experiments and offer training courses that cover most aspects of a proteomics experiment. The facility is open to all Oxford researchers as well as external academic and commercial users.

Find out more at: http://www.proteomics.ox.ac.uk/

Advanced Fluorescence Microscopy

Micron Oxford is an advanced Bioimaging Unit developing and applying cutting edge technologies as well as providing diverse advanced imaging facilities. They help users perform optimum imaging experiments to address their biological questions, offering advice training and advice on experimental design, specimen preparation, image analysis and data storage.

NMR Spectroscopy

Solution-state Nuclear Magnetic Resonance (NMR) spectroscopy is a method that provides detailed information about the structure, dynamics and interactions of biological macromolecules under conditions that can mimic the cellular environment.

Molecular Biophysics

We offer a range of techniques to study macromolecules and macromolecular complexes. These include analytical ultracentrifugation, differential scanning calorimetry, electrospray ionization mass spectrometry, isothermal titration calorimetry and surface plasmon resonance. All users must be registered with Dr David Staunton and receive any necessary training.

Crystallography

The Crystallography Facility enables you to apply the methods of X-ray crystallography to your biological questions. We can offer both state of the art equipment and expert advice and training in the use of crystallography for structural biology.

Visualising how a malaria parasite invades human red blood cells

Members of the Higgins group have made new discoveries about how malaria parasites get inside our red blood cells...

Members of the Higgins group have made new discoveries about how malaria parasites get inside our red blood cells which might help them to design new vaccines

COVID Moonshot initiative identifies novel antiviral compound

The first-ever crowd-sourced small molecule discovery effort has been published in Science

Armed to the hilt: Study solves mystery behind bacteria’s extensive weaponry

A new study has shed light on why certain species of bacteria carry astonishing arsenals of weapons

Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method

The lab of Fanni Gergely has developed a new affinity-based method that allows rapid isolation of centrosomes for...

The lab of Fanni Gergely has developed a new affinity-based method that allows rapid isolation of centrosomes for proteomic profiling

Scientists Discover Enzyme That Turns Air Into Electricity, Providing A New Clean Source Of Energy

A team of scientists have discovered an enzyme that converts air into energy

Research reveals the first molecular understanding of BIRC6 – an essential regulator of cell death

Latest research from the group of Paul Elliott has uncovered how BIRC6 (a giant ubiquitin ligase) protects cells...

Latest research from the group of Paul Elliott has uncovered how BIRC6 (a giant ubiquitin ligase) protects cells from death and how this can be antagonised

New Publication: "GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation"

Neutrophils are a type of white blood cell that are part of our innate immune system. Their activities require...

Neutrophils are a type of white blood cell that are part of our innate immune system. Their activities require tight regulation to avoid unwanted inflammation and autoimmune diseas...

Neutrophils are a type of white blood cell that are part of our innate immune system. Their activities require tight regulation to avoid unwanted inflammation and autoimmune diseases.

Bacterial armour plating has implications for antibiotics

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct...

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armour, which has far-reaching...

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armour, which has far-reaching implications for the development...

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armour, which has far-reaching implications for the development of antibiotics

A collaborative study between Oxford, Glasgow and UKHSA discovers unexpected differences in the replication of SARS-CoV-2 variants of concern

A new study reveals differences in replication rates of SARS-CoV-2 variants of concern using single molecule RNA...

A new study reveals differences in replication rates of SARS-CoV-2 variants of concern using single molecule RNA detection

One cell, two genomes? Coordination between mitochondria and the nucleus in cancer

New paper from the Peter Sarkies research group

New therapeutic possibilities at the ‘heart’ of SARS-CoV-2 life cycle

A team led by researchers at the University of Oxford, University of Glasgow, and University of Heidelberg, uncovers...

A team led by researchers at the University of Oxford, University of Glasgow, and University of Heidelberg, uncovers the interactions that SARS-CoV-2 RNA establishes with the host cell,...

A team led by researchers at the University of Oxford, University of Glasgow, and University of Heidelberg, uncovers the interactions that SARS-CoV-2 RNA establishes with the host cell, paving the way for the development...

A team led by researchers at the University of Oxford, University of Glasgow, and University of Heidelberg, uncovers the interactions that SARS-CoV-2 RNA establishes with the host cell, paving the way for the development of new therapeutic strategies

Structure of the folate transporter paves the way for improved anticancer drugs

A new study from the Newstead group, published in Nature, reveals the structure of the folate transporter, laying...

A new study from the Newstead group, published in Nature, reveals the structure of the folate transporter, laying the foundation for developing targeted anticancer drugs

Advanced Proteomics Facility

Facility information

Other facilities

Advanced Fluorescence Microscopy

NMR Spectroscopy

Molecular Biophysics

Crystallography

Latest discoveries

Visualising how a malaria parasite invades human red blood cells

COVID Moonshot initiative identifies novel antiviral compound

Armed to the hilt: Study solves mystery behind bacteria’s extensive weaponry

Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method

Scientists Discover Enzyme That Turns Air Into Electricity, Providing A New Clean Source Of Energy

Research reveals the first molecular understanding of BIRC6 – an essential regulator of cell death

New Publication: "GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation"

Bacterial armour plating has implications for antibiotics

A collaborative study between Oxford, Glasgow and UKHSA discovers unexpected differences in the replication of SARS-CoV-2 variants of concern

One cell, two genomes? Coordination between mitochondria and the nucleus in cancer

New therapeutic possibilities at the ‘heart’ of SARS-CoV-2 life cycle

Structure of the folate transporter paves the way for improved anticancer drugs