Dr Haoxi Wu

Dr Haoxi Wu

Membrane protein homeostasis

The human genome encodes ~5,000 membrane proteins that are essential for life. The surveillance of pathogen invasion, the ability to visualize, communicate, and process information, and the production of energy to sustain life, all rely on membrane proteins. 

Within our cells, membrane proteins of varied sizes, shapes, and biophysical properties, are first made in the cytosol. To function properly, most of these proteins need to be targeted to the correct membrane, inserted in the appropriate orientation, folded into their three-dimensional structure, assembled with partners, and trafficked to their final destination for function. Our group is broadly interested in the molecular details of the life cycle of membrane proteins. 

Our current focus revolves around understanding how multi-subunit protein complexes are assembled on the membrane. We use multi-disciplinary approaches to identify and characterise factors important for complex assembly, trafficking, and degradation of subunits that aren't incorporated into a complex.

Our work uncovers the fundamental principles governing membrane protein complex formation and opens new avenues for therapeutic intervention.