Resolving structural details of membrane peptides and proteins at high resolution
Undestanding how biological membranes work is still a major challenge, and one we address using a range of biophysical methods from magnetic resonance to microscopy, functional assays and simulation. Of particular interest are G-protein coupled receptors that are major drug targets, and photoreceptors. Most recently we have studied the functional significance of receptor oligomerization using single molecule and spectroscopic methods, and the fast changes induced by light in photoreceptors using time resolved, photoinduced XFELs. In all these systems, functional integrity is paramount.